The Coquihalla Highway between Merritt and Hope is expected to get a big dump of snow.
Environment Canada says between 15 and 25 cm will fall between tonight and early Saturday evening.
It's a result of "an intense Pacific frontal system" that will cross the Interior.
"Meanwhile, strong southerly winds accompanying the system will give local blowing snow resulting in low visibilities," reads the snowfall warning.
Drivers are encouraged to be prepared for hazardous driving conditions.
For the latest road conditions, visit drivebc.ca.